Effect of Metformin on C-reactive Protein in Type 2 Diabetes Mellitus Patients

Diabetes mellitus (DM) is a complex endocrinology disease which requires meticulous understanding of its pathogenesis and complications to subdue it. It has been riddled with extensive micro macro vascular by itself own set pathogenesis. There link between DM cardiovascular (CVD), the most important cause morbidity mortality in diabetic patients. Cardiovascular risk factors such as obesity, hypertension dyslipidemia are more common patients DM, placing them at increased for cardiac events. In addition, they have found biological mechanisms associated that independently increases CVD patients.Metformin commonly used antidiabetic agent derived from Gallegaofficinalis. Metformin provided greater protection against than would be expected effects upon glycemic control alone. Hence this study evaluated anti-inflammatory effect metformin on C Reactive Protein (CRP) fifty type 2 diabetes were enrolled including 23 males 27 females mean age 40±4.33. FBS PPBS baseline values expressed Mean ± SD 138.06±17.12 mg/dl 223.12±30.63 respectively. After 6 months therapy, 91.64±10.55 133.88±7.99 HBA1C value was 7.966±0.85 %. improved 6.8±0.93.hs-CRP Mean±SD 3.4±1.16 mg/L. hs - CRP effectively reduced 1.7±0.81 Prompt treatment intensification cases may thus sensible. Further studies needed identify predictors response, especially focusing hs-CRP levels, lipid levels genetic factors.